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The -O-P-O bonds beyond the first one are actually phosphoric anhydride linkages.

The ionized forms are frequently associated with divalent cations (Mg2+, Mn2+, others).

They can dissociate 3 protons (XDP) or 4 protons (XTP) from their phosphoric acid groups.

Phosphoanhydride bonds link second and perhaps third phosphates to the 5’-OH on the ribose moiety Biochemistry: Nucleic Acid Chem&Struct.

cAMP and cGMP are the important ones(see previous lecture!) Biochemistry: Nucleic Acid Chem&Struct.

3’ and 5’ hydroxyls are both involvedin -O-P-O bonds, forming a 6-membered ring (-C5’-C4’-C3’-O-P-O-).

dTTP (= TTP) = deoxythymidylate = thymidylate Biochemistry: Nucleic Acid Chem&Struct.

These aromatic rings absorb around 260 Biochemistry: Nucleic Acid Chem&Struct.

PKa’s for base N’s and PO4’s Biochemistry: Nucleic Acid Chem&Struct

UMP = uridylate Biochemistry: Nucleic Acid Chem&Struct.

Adenosine 5’-monophosphate = AMP = adenylate.

We have specialized names for the 5’-phospho derivatives of the nucleosides, i.e.

Syn versus anti Biochemistry: Nucleic Acid Chem&Struct

RNA: structure & types Biochemistry: Nucleic Acid Chem&Struct.Nucleic AcidChemistry & Structure Andy HowardIntroductory Biochemistry2 October 2008 Biochemistry: Nucleic Acid Chem&Struct